Opiate-based drugs have many drawbacks. They often bring to the patient both insignificant discomfort, like intestinal obstruction, and a serious danger to life, such as a respiratory distress syndrome. But modern medicine cannot abandon opiates: they are extremely effective in coping with pain. Unfortunately, until now, scientists have not been able to do so that opioid drugs bring only one benefit.
But this problem is in the past. Researchers have found a new way of opioid that will affects only selective inflamed tissues. Theoretically, such a drug not only alleviates the pain, but also does not cause side effects and addictions. The invention has already been tested in rats, and the result was purely positive, so in the near future the new drug can become a real panacea for various types of pain.
Buy Morphine is one of strong Opiate base drug that have many benefits and disadvantages as well.
Opioids affect the special receptors located throughout the human body. Molecules of matter are compatible with them as a key with a lock, and when they interact, dopamine is released into the blood, which also suppresses pain. This is very good for sore areas, but for strong tissues the welfares are highly questionable. When opioids attach to receptors in the brain, they can interact with nerves that control the respiratory rate of a person, slowing it down to a dangerously low level. In the gastrointestinal tract, opioids can also negatively affect the nervous system, causing intestinal obstruction (in other words, constipation). In addition to all of the above, the release of dolphin causes euphoria and relaxation, which in the future can with high probability provoke drug dependence.
But what if we create such an anesthetic that will selectively interact with opioid receptors only in damaged tissues? To find this out, a group of researchers first analyzed what distinguishes inflamed tissues from healthy from the acidity point of view. It turned out that the acidity of the damaged areas is much higher than that of the healthy ones, which means that it was a small matter: the opioids that bind to receptors only under conditions of increased kiloarticle were obtained by laboratory means.
Christophe Stein, professor at the Department of Anaesthesiology and Intensive Care at the Free University of Berlin and co-author of the article assures that such measures eliminate the risk of side effects and addictions – opioids simply do not bind to the receptors either in the GI tract or in the brain. The results of the study of his team were published the other day in the journal Science. The new drug is called NFEPP, and its tests in rats were positive: rodents ceased to feel pain without any respiratory or gastric discomfort. Even after several rats were kept on opioids for a long time, after a sharp cancellation of the dose, they did not react to this fact, although usually the opioid dependence in rats develops approximately the same as in humans. With regard to efficacy, the new drug and the old, long-proven “fentanyl” agent proved to be equally effective.
The next step, according to Stein, will be testing the drug in public. Unfortunately, here bureaucratic red tape comes into play, so scientists will be lucky if all the necessary permits are received for at least the next few months. If their work is crowned with success, then this can be a real revolution in the field of pain medication.